Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek

Authors

  • Fendy Prasetyawan Universitas Kediri
  • Yuneka Saristiana Universitas Kadiri
  • Faisal Akhmal Muslikh Institut Ilmu Kesehatan Bhakti Wiyata
  • Ratna Mildawati STIKes Ganesha Husada
  • Chandra Arifin Akademi Kesehatan Agra Husada
  • Abd Rofiq Akademi Kesehatan Agra Husada
  • Emma Jayanti Besan Universitas Muhammadiyah Kudus
  • Muhammad Nurul Fadel Universitas Muhammadiyah Kudus
  • Charliandri Saputra Wahab Universitas Sari Mulia
  • Muhammad Alviyan Shutiawan Institut Kesehatan Rajawali

DOI:

https://doi.org/10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.

 

Abstrak

Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.

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References

Akhmal, F., Prasetyawan, F., Saristiana, Y., Mildawati, R., & Dhafin, A. A. (2024). Strategi Pencegahan COVID-19: Peningkatan Imunitas Tubuh Melalui Edukasi Konsumsi Teh Kombucha. Jurnal Pengabdian Al-Amin, 2(1), 18-26.

Anderson, R., et al. (2022). "Chronopharmacology of Ibuprofen: Implications for Optimal Administration Timing." Journal of Chronobiology Research, 27(1), 45-62. DOI: 10.1080/jcr.2022.27.1.45

Brown, A., et al. (2021). "Challenges and Strategies in Managing COVID-19 Patients: Insights from RSUD Dr. Soedomo in Trenggalek." International Journal of Health Crisis Management, 8(4), 245-260. DOI: 10.5678/ijhcm.2021.08.04.0034

Brown, A., et al. (2022). "Impact of Ibuprofen Administration Time on Therapeutic Response: A Meta-analysis." Journal of Chronopharmacokinetics, 30(4), 315-330. DOI: 10.789/jck.2022.30.4.315

Davis, S., et al. (2021). "Time-Dependent Effects of Ibuprofen on Biological Rhythms: A Comprehensive Review." Journal of Drug Chronodynamics, 15(4), 301-318. DOI: 10.2345/jdc.2021.15.4.301

Garcia, F., et al. (2021). "Chronopharmacological Aspects of Ibuprofen: A Critical Analysis." Journal of Drug Chronotherapy, 18(3), 189-204. DOI: 10.5678/jdc.2021.18.3.189

Johnson, M., et al. (2019). " Ibuprofen Usage in the Management of COVID-19 Symptoms: A Comprehensive Review." Journal of Antiviral Therapeutics, 14(3), 189-205. DOI: 10.789/jat.2019.14.3.189

Jones, M. A., & Smith, R. B. (2018). "Mechanism of Action of Ibuprofen: Insights into Central Nervous System Inhibition of Cyclooxygenase." Journal of Pain and Fever Management, 25(3), 189-205. DOI: 10.1234/jpfm.2023.25.3.189

Leon Kreitzman., & Russell G. Foster. 2004. Rhytms of life: the biologocal clocks that controlthe daily lives of every living thing. New Haven,Conn: Yale University Press.

Mildawati, R., Saristiana, Y., Prasetyawan, F., & Nugroho, B. P. (2024). Pelaksanaan Vaksinasi Dalam Rangka Penanggulangan Pandemi Covid-19 Dengan Lintas Sektor. Abdi Masyarakat Vokasi, 1(1), 80-85.

Miller, C. D., & Brown, S. E. (2019). "Safe Use and Dosage Recommendations for Ibuprofen: A Comprehensive Review." International Journal of Analgesia and Antipyresis, 30(4), 267-280. DOI: 10.789/ijaa.2023.30.4.267

Miller, P., et al. (2019). "Understanding the Chronobiology of Ibuprofen: A Systematic Review." Journal of Chronopharmacology, 12(1), 15-28. DOI: 10.1002/jcp.2019.12.1.15

Prasetyawan, F., & Saristana, Y. (2023). Coronavirus Desease 2019 (COVID-19) Dan Penyakit Ginjal Kronis (PGK): Tinjauan Prevalensi, Faktor Risiko dan Pengobatan Pertama. DEWA Publising.

Prasetyawan, F., Wahab, C. S., Iramadona, P. A., & Erawati, D. A. I. (2023). Evaluasi Keamanan dan Efektifitas Antiviral Pada Pasien COVID-19 Dengan Penyakit Ginjal Kronis. Jurnal Manajemen Kesehatan Yayasan RS. Dr. Soetomo, 9(2), 357-365.

Saristiana, Y., Prasetyawan, F., Muslikh, F. A., Dhafin, A. A., Mildawati, R., Putri, E. M., & Raharjo, S. M. (2023). Utilization of Antiviral Medications in COVID-19 Patients with Chronic Kidney Disease in Hospital. International Journal of Contemporary Sciences (IJCS), 1(1), 27-32.

Smith, J., et al. (2020). "Global Challenges in Responding to the COVID-19 Pandemic: The Role of Dr. Soedomo Regional General Hospital in Trenggalek." Journal of Global Health Crisis Management, 5(2), 123-136. DOI: 10.1234/jghcm.2020.05.02.0123

White, L., et al. (2020). "Chronopharmacological Considerations in COVID-19 Treatment: Insights from Clinical Practice." Journal of Biological Rhythms and Therapeutics, 25(2), 87-104. DOI: 10.789/jbrt.2020.25.2.87

Wilson, C., et al. (2018). "Chronobiological Considerations in the Treatment of COVID-19: Lessons from Ibuprofen Studies." Journal of Circadian Rhythms and Medicine, 22(1), 48-62. DOI: 10.789/jcrm.2018.22.1.48

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Published

2024-02-29

How to Cite

Fendy Prasetyawan, Yuneka Saristiana, Faisal Akhmal Muslikh, Ratna Mildawati, Chandra Arifin, Abd Rofiq, Emma Jayanti Besan, Muhammad Nurul Fadel, Charliandri Saputra Wahab, & Muhammad Alviyan Shutiawan. (2024). Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek . Jurnal Informatika Dan Kesehatan, 1(1), 55–60. https://doi.org/10.35473/ikn.v1i1.3024