Paparan PM2.5 dan Risiko Penyakit Pernapasan pada Kelompok Rentan di Wilayah Urban: Systematic Review
Keywords:
PM2.5, Penyakit Pernapasan, Kelompok Rentan, Wilayah UrbanAbstract
ABSTRAK
Polusi udara khususnya Particulate Matter 2.5 (PM2.5), merupakan masalah kesehatan lingkungan yang terus meningkat di wilayah urban dan berdampak terhadap kesehatan pernapasan. Menurut WHO pada 2019 polusi udara luar ruangan diperkirakan menyebabkan 4,2 juta kematian prematur di seluruh dunia. Kelompok rentan seperti anak-anak, lansia, dan individu dengan penyakit komorbid memiliki risiko tinggi mengalami gangguan pernapasan akibat paparan PM2.5. Penelitian ini bertujuan mengkaji hubungan antara paparan PM2.5 dan risiko penyakit pernapasan pada kelompok rentan di wilayah urban. Metode penelitian menggunakan Systematic Literature Review (SLR) dengan kerangka PECO (Population, Exposure, Comparison, Outcome) dan Diagram PRISMA Flow. Pencarian artikel melalui basis data Google Scholar dan ScienceDirect dengan hasil awal 5.086 artikel, 732 dari Google Scholar dan 4.354 dari ScienceDirect. Setelah penyaringan berdasarkan rentang tahun publikasi 2021–2026, status open access, duplikasi, skrining, dan penilaian kelayakan, diperoleh 13 artikel yang memenuhi kriteria. Penilaian kualitas artikel menggunakan Joanna Briggs Institute (JBI) Critical Appraisal Tool. Hasil analisis menunjukkan sebagian besar artikel melaporkan hubungan positif antara paparan PM2.5 di wilayah urban dengan peningkatan risiko gangguan pernapasan pada kelompok rentan. Anak-anak menjadi kelompok paling rentan terhadap ISPA, asma, dan pneumonia. Pada lansia dan penderita komorbid, paparan jangka panjang mempercepat penurunan fungsi fisiologis dan memperburuk kondisi klinis. Pada masyarakat urban, risiko bersifat multifaktorial dipengaruhi faktor perilaku, sosial ekonomi, dan aktivitas luar ruangan. Disimpulkan bahwa paparan PM2.5 di wilayah urban berhubungan positif dengan peningkatan risiko gangguan kesehatan pernapasan pada kelompok rentan dengan kerentanan bervariasi sesuai karakteristik fisiologis dan faktor risiko penyerta.
Kata kunci: PM2.5, Penyakit Pernapasan, Kelompok Rentan, Wilayah Urban
ABSTRACT
Air pollution, particularly Particulate Matter 2.5 (PM2.5), is a growing environmental health problem in urban areas that negatively affects respiratory health. According to the WHO (2024), outdoor air pollution was estimated to have caused 4.2 million premature deaths worldwide in 2019. Vulnerable groups such as children, the elderly, and individuals with comorbidities are at high risk of developing respiratory disorders due to PM2.5 exposure. This study aims to examine the relationship between PM2.5 exposure and the risk of respiratory disease among vulnerable populations in urban areas. The method used is a Systematic Literature Review (SLR) based on the PECO framework (Population, Exposure, Comparison, Outcome) and the PRISMA Flow Diagram. Articles were searched through the Google Scholar and ScienceDirect databases, yielding an initial total of 5,086 articles, 732 from Google Scholar and 4,354 from ScienceDirect. After filtering based on publication year (2021–2026), open-access status, duplication removal, screening, and eligibility assessment, 13 articles met the inclusion criteria. The quality of the selected articles was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tool. The results show that most articles reported a positive association between PM2.5 exposure in urban areas and an increased risk of respiratory disorders among vulnerable groups. Children were found to be the most vulnerable group to acute respiratory infections, asthma, and pneumonia. In the elderly and those with comorbidities, long-term exposure accelerated physiological decline and worsened clinical conditions. Among the urban population, risk was multifactorial, influenced by behavioral, socioeconomic, and outdoor activity factors. It is concluded that PM2.5 exposure in urban areas is positively associated with increased respiratory health risks among vulnerable groups, with susceptibility varying according to physiological characteristics and accompanying risk factors.
Keywords: PM2.5, Respiratory Diseases, Vulnerable Groups, Urban Areas
References
1. World Health Organization. WHO global air quality guidelines: particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. 2021.
2. Jonidi Jafari A, Charkhloo E, Pasalari H. Urban air pollution control policies and strategies: a systematic review. J Environ Health Sci Eng. 2021 Dec;19(2):1911–40. doi:10.1007/s40201-021-00744-4 PubMed PMID: 34900316.
3. Clean Air Asia, Kementerian Lingkungan Hidup Republik Indonesia. Menuju Udara Bersih Jabodetabek: Sinergi Kementerian dan Daerah untuk Aksi Kolektif. 2025.
4. IQAir. 2025 World Air Quality Report. 2026.
5. IQAir. IQAir. 2026. Indonesia Air Quality Index (AQI) and Air Pollution Information.
6. Eurostat. Respiratory Diseases Statistics. 2025.
7. Eka Lolita Eliyanti Pakpahan, Enni Halimatussadiyah Pakpahan. HUBUNGAN PAPARAN POLUSI UDARA PM2,5 DENGAN RISIKO GANGGUAN KESEHATAN MASYARAKAT DI WILAYAH PERKOTAAN. Al-Tamimi Kesmas: Jurnal Ilmu Kesehatan Masyarakat (Journal of Public Health Sciences). 2025 Dec 31;14(2):254–62. doi:10.35328/kesmas.v14i2.3137
8. Indonesia Environment & Energy Center (IEC). Daftar Polusi Udara 2025: Jenis, Penyebab, dan Solusi. 2025.
9. Kartika Dian Pertiwi, Ita Puji Lestari, Alfan Afandi. Analisis Risiko Kesehatan Lingkungan Pajanan Debu PM10 dan PM2.5 pada Relawan Lalu Lintas di Jalan Diponegoro Ungaran. Pro Health: Jurnal Ilmiah Kesehatan. 2024;6(2):85–91.
10. deSouza P, Boing AF, Kim R, Subramanian S. Associations between ambient PM2.5 – components and age-specific mortality risk in the United States. Environmental Advances. 2022 Oct;9:100289. doi:10.1016/j.envadv.2022.100289
11. Liu K, Hua S, Song L. PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress. Oxid Med Cell Longev. 2022 Jan 4;2022(1). doi:10.1155/2022/3618806
12. Krishna M, Madden J, Teran L, Biscione G, Lau L, Withers N, et al. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. European Respiratory Journal. 1998 Jun 1;11(6):1294–300. doi:10.1183/09031936.98.11061294
13. Bateson TF, Schwartz J. Children’s Response to Air Pollutants. J Toxicol Environ Health A. 2008 Feb 20;71(3):238–43. doi:10.1080/15287390701598234
14. Hahad O, Frenis K, Kuntic M, Daiber A, Münzel T. Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure. Int J Mol Sci. 2021 Feb 28;22(5):2419. doi:10.3390/ijms22052419
15. Basith S, Manavalan B, Shin TH, Park CB, Lee WS, Kim J, et al. The Impact of Fine Particulate Matter 2.5 on the Cardiovascular System: A Review of the Invisible Killer. Nanomaterials. 2022 Aug 2;12(15):2656. doi:10.3390/nano12152656
16. Wang C, Tu Y, Yu Z, Lu R. PM2.5 and Cardiovascular Diseases in the Elderly: An Overview. Int J Environ Res Public Health. 2015 Jul 16;12(7):8187–97. doi:10.3390/ijerph120708187
17. Franck U, Odeh S, Wiedensohler A, Wehner B, Herbarth O. The effect of particle size on cardiovascular disorders — The smaller the worse. Science of The Total Environment. 2011 Sep;409(20):4217–21. doi:10.1016/j.scitotenv.2011.05.049
18. VALAVANIDIS A, FIOTAKIS K, VLACHOGIANNI T. Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms. Journal of Environmental Science and Health, Part C. 2008 Dec 2;26(4):339–62. doi:10.1080/10590500802494538
19. Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, et al. Do Inhaled Carbon Nanoparticles Translocate Directly into the Circulation in Humans? Am J Respir Crit Care Med. 2006 Feb 15;173(4):426–31. doi:10.1164/rccm.200506-865OC
20. NEMMAR A, VANBILLOEN H, HOYLAERTS MF, HOET PHM, VERBRUGGEN A, NEMERY B. Passage of Intratracheally Instilled Ultrafine Particles from the Lung into the Systemic Circulation in Hamster. Am J Respir Crit Care Med. 2001 Nov 1;164(9):1665–8. doi:10.1164/ajrccm.164.9.2101036
21. Chu Z, Qu Y, Wang Y, Cao Y, Cao Y, Guo B, et al. Association between PM2.5 exposure with major adverse cardiovascular events and the modification of medical history and green space: A cohort study. Ecotoxicol Environ Saf. 2025 Nov;306:119367. doi:10.1016/j.ecoenv.2025.119367
22. Adjorlolo PK, Attey-Yeboah P, Molitor J, Coker ES, Aheto JM, Amegah AK. Spatial variability in the association of ambient PM2.5 exposure with acute respiratory infection among children in Sub-Saharan Africa. Environ Res. 2026 Jun;299:124297. doi:10.1016/j.envres.2026.124297
23. Wahyu Setiaji. Paparan Particulate Matter 2.5 (PM2.5) dan Iklim Mikro sebagai Faktor Risiko pada Pneumonia Balita di Daerah Perkotaan. AT-TAKLIM: Jurnal Pendidikan Multidisiplin. 2025;2(8):85–100.
24. Wei S, Luo Z, Lannon S, Sharmin T, Smith J, Zhang H, et al. Personal air pollution exposure assessment with schoolchildren in rural Wales. J Environ Manage. 2026 Jan;397:128291. doi:10.1016/j.jenvman.2025.128291
25. Shumake KL, Sacks JD, Lee JS, Johns DO. Susceptibility of older adults to health effects induced by ambient air pollutants regulated by the European Union and the United States. Aging Clin Exp Res. 2013 Apr 18;25(1):3–8. doi:10.1007/s40520-013-0001-5
26. Wan L, Bambrick H, Tong M. Mortality attributable to ambient PM2.5 pollution in China’s aging population. Environ Impact Assess Rev. 2025 Mar;112:107823. doi:10.1016/j.eiar.2025.107823
27. Matthew J. Page, Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, et al. The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews. The BMJ. 2021;372:n71.
28. Yu-Fei Xing, Yue-Hua Xu, Min-Hua Shi, Yi-Xin Lian. The impact of PM2.5 on the human respiratory system. J Thorac Dis. 2016;8(1):E69–74.
29. Liu S, Liu J, Wang Y, Deng F, Deng Z. Oxidative Stress: Signaling Pathways, Biological Functions, and Disease. MedComm (Beijing). 2025 Jul;6(7). doi:10.1002/mco2.70268
30. Haryono. Buku Ajar Sanitasi Lingkungan: Pengantar Epidemiologi. Poltekkes Jogja Press; 2021.
31. Amnuaylojaroen T, Parasin N. Future Health Risk Assessment of Exposure to PM2.5 in Different Age Groups of Children in Northern Thailand. Toxics. 2023 Mar 22;11(3):291. doi:10.3390/toxics11030291
32. IQAir. WHO Air Quality Guidelines: What They Mean and Why They Matter. 2021.
33. Heinz A. Elastic fibers during aging and disease. Ageing Res Rev. 2021 Mar;66:101255. doi:10.1016/j.arr.2021.101255
34. Allen JC, Toapanta FR, Chen W, Tennant SM. Understanding immunosenescence and its impact on vaccination of older adults. Vaccine. 2020 Dec;38(52):8264–72. doi:10.1016/j.vaccine.2020.11.002
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